Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies
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چکیده
منابع مشابه
Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies
Functional knockdowns mediated by endoplasmatic reticulum-retained antibodies (ER intrabodies) are a promising tool for research because they allow functional interference on the protein level. We demonstrate for the first time that ER intrabodies can induce a knock-down phenotype in mice. Surface VCAM1 was suppressed in bone marrow of heterozygous and homozygous ER intrabody mice (iER-VCAM1 mi...
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ژورنال
عنوان ژورنال: mAbs
سال: 2014
ISSN: 1942-0862,1942-0870
DOI: 10.4161/mabs.34377